In 2004, Seyfried made her film debut in Mean Girls playing Karen Smith, the ditziest of the so-called "Plastics". Her subsequent roles as a supporting character were in independent films like Nine Lives (2005) and Alpha Dog (2006). She also had a recurring role in the UPN TV show Veronica Mars (2004–2006). Between 2006 and 2010, she landed a lead role on HBO's popular television series Big Love. After that, Seyfried appeared in her breakthrough and first leading role as Sophie Sheridan in the 2008 musical feature film Mamma Mia!. Other recent appearances include successful leading roles in Jennifer's Body (2009), Chloe (2010), Dear John (2010), Letters to Juliet (2010), and Red Riding Hood (2011).
In 2003, Seyfried auditioned to play the role of Regina George in Mean Girls; the role eventually went to Rachel McAdams. While she was initially considered to play the lead role of Cady Heron, played by Lindsay Lohan, the producers of the film decided that Seyfried should play Karen Smith, Regina's dim-witted "Plastic" friend and sidekick. The film was a box-office success, earning over $129 million in its theatrical run.Seyfried's performance in the film earned her, along with Lohan, Chabert and McAdams, an MTV Movie Award in the category of "Best On-Screen Team". Seyfried auditioned to play the title character on UPN's television series Veronica Mars.The role eventually went to Kristen Bell, and Seyfried portrayed the title character's murdered best friend, Lilly Kane. Her character was only shown in flashbacks. The creator, Rob Thomas felt that Seyfried's portrayal as Lilly Kane was outstanding that he used her more times in the show than he initially planned in the first season. Seyfried appeared in ten episodes from 2004–2005.
Seyfried's profile gained prominence due to her role in the highly acclaimed HBO drama television series, Big Love. The series centers on a fictional fundamentalist Mormon family, in which Seyfried plays Sarah Henrickson, Bill and Barb's first daughter, who struggles with her family's polygamous faith. Big Love premiered in the United States on March 12, 2006. In December 2009, HBO confirmed that Seyfried would return for the show's fourth season, but that it would be her last, as Seyfried wished to focus on her film career and upcoming projects.Following Big Love, Seyfried had a supporting role as Zoe in the 2008 horror drama film Solstice, and she co-starred alongside Meryl Streep in Mamma Mia!, a romantic comedy film adaptation of the 1999 musical of the same name Mamma Mia! was Seyfried's first leading role. The film was the fifth highest grossing film of 2008 and, as of March 2010, is the 49th highest grossing film of all time. Her musical performance in Mamma Mia! was released on the film's soundtrack, for which she recorded five songs. As part of promotion for both the film and its soundtrack, Seyfried recorded a music video of the song, entitled "Gimme! Gimme! Gimme! (A Man After Midnight)".
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